Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.
第一作者:
A,Hombrouck
第一单位:
Laboratory for Molecular Virology and Drug Discovery, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium.
作者:
主题词
抗HIV药(Anti-HIV Agents);细胞系(Cell Line);化学现象(Chemical Phenomena);化学, 物理(Chemistry, Physical);DNA, 病毒(DNA, Viral);抗药性, 病毒(Drug Resistance, Viral);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);HIV包膜蛋白质gp160(HIV Envelope Protein gp160);HIV感染(HIV Infections);HIV逆转录酶(HIV Reverse Transcriptase);HIV-1(HIV-1);人类(Humans);整合酶类(Integrases);慢病毒属(Lentivirus);寡核苷酸类(Oligonucleotides);质粒(Plasmids);吡喃类(Pyrans);嘧啶类(Pyrimidines);重组, 遗传(Recombination, Genetic);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);转导, 遗传(Transduction, Genetic)
DOI
10.1093/jac/dkm101
PMID
17470918
发布时间
2016-11-24
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