Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.
第一作者:
N A,Shadick
第一单位:
Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. nshadick@partners.org
作者:
医学主题词
成年人(Adult);老年人(Aged);等位基因(Alleles);关节炎, 类风湿(Arthritis, Rheumatoid);互补决定区(Complementarity Determining Regions);疾病恶化(Disease Progression);表位(Epitopes);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);HLA-DR4抗原(HLA-DR4 Antigen);组织相容性试验(Histocompatibility Testing);人类(Humans);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);表型(Phenotype);疾病严重程度指数(Severity of Illness Index);时间因素(Time Factors)
DOI
10.1136/ard.2006.067603
PMID
17491100
发布时间
2025-02-14
- 浏览22
Annals of the rheumatic diseases
1497-502页
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