Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.
第一作者:
Constantinos,Brikos
第一单位:
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK. brikosc@tcd.ie
作者:
医学主题词
细胞分化(Cell Differentiation);电泳, 聚丙烯酰氨凝胶(Electrophoresis, Polyacrylamide Gel);人类(Humans);免疫沉淀法(Immunoprecipitation);白细胞介素1受体辅助蛋白质(Interleukin-1 Receptor Accessory Protein);白细胞介素1受体相关激酶类(Interleukin-1 Receptor-Associated Kinases);配体(Ligands);质谱分析法(Mass Spectrometry);髓样分化因子88(Myeloid Differentiation Factor 88);磷氨基酸类(Phosphoamino Acids);磷酰化(Phosphorylation);蛋白质组学(Proteomics);受体, 白细胞介素1(Receptors, Interleukin-1);信号传导(Signal Transduction);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization)
DOI
10.1074/mcp.M600455-MCP200
PMID
17507369
发布时间
2025-05-29
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