换一批
换一批Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
作者：
主题词
投药, 口服(Administration, Oral);动物(Animals);生物利用度(Biological Availability);结晶学, X线(Crystallography, X-Ray);狗(Dogs);低血压(Hypotension);吲唑类(Indazoles);小鼠(Mice);模型, 分子(Models, Molecular);蛋白质构象(Protein Conformation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);浦肯野纤维(Purkinje Fibers);吡唑类(Pyrazoles);吡啶类(Pyridines);大鼠(Rats);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm0701019
PMID
17523610
发布时间
2009-11-19
- 浏览25
Journal of medicinal chemistry
2990-3003页
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