The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);降钙素(Calcitonin);二苯脲类(Carbanilides);细胞系, 肿瘤(Cell Line, Tumor);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);胶质细胞源性神经营养因子(Glial Cell Line-Derived Neurotrophic Factor);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);肿瘤移植(Neoplasm Transplantation);磷酰化(Phosphorylation);原癌基因蛋白质c-ret(Proto-Oncogene Proteins c-ret);甲状腺肿瘤(Thyroid Neoplasms)
DOI
10.1158/0008-5472.CAN-06-4605
PMID
17638907
发布时间
2009-11-19
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Cancer research
6956-64页
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