Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes.
作者:
主题词
动物(Animals);动物, 新生(Animals, Newborn);星形细胞(Astrocytes);组织蛋白酶D(Cathepsin D);细胞死亡(Cell Death);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);环GMP(Cyclic GMP);环GMP依赖性蛋白激酶类(Cyclic GMP-Dependent Protein Kinases);细胞保护(Cytoprotection);胞质溶胶(Cytosol);去铁胺(Deferoxamine);剂量效应关系, 药物(Dose-Response Relationship, Drug);过氧化氢(Hydrogen Peroxide);细胞内膜(Intracellular Membranes);L-乳酸脱氢酶(L-Lactate Dehydrogenase);溶酶体(Lysosomes);膜电位, 线粒体(Membrane Potential, Mitochondrial);线粒体(Mitochondria);氧化性应激(Oxidative Stress);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);预防和防护用药(Protective Agents);嘌呤酮类(Purinones);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);活性氧(Reactive Oxygen Species);鱼藤酮(Rotenone);鞘氨醇(Sphingosine);硫代核苷酸类(Thionucleotides);解偶联药(Uncoupling Agents)
DOI
10.1016/j.ejphar.2007.06.042
PMID
17643412
发布时间
2013-11-21
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