换一批
换一批2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
作者：
主题词
乙酰化作用(Acetylation);丙烯酰胺类(Acrylamides);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);苯呋喃类(Benzofurans);细胞周期(Cell Cycle);细胞提取物(Cell Extracts);细胞系, 肿瘤(Cell Line, Tumor);药物设计(Drug Design);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);组蛋白脱乙酰基酶1(Histone Deacetylase 1);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);组蛋白类(Histones);人类(Humans);羟肟酸类(Hydroxamic Acids);吲哚类(Indoles);磷酰化(Phosphorylation);重组蛋白质类(Recombinant Proteins);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm0703136
PMID
17691763
发布时间
2018-12-01
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