Generation of chimeric HBc proteins with epitopes in E.coli: formation of virus-like particles and a potent inducer of antigen-specific cytotoxic immune response and anti-tumor effect in vivo.
第一作者:
Yan,Zhang
第一单位:
Department of Molecular Biology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, PR China.
作者:
医学主题词
动物(Animals);抗体特异性(Antibody Specificity);抗原, 肿瘤(Antigens, Neoplasm);癌, 肝细胞(Carcinoma, Hepatocellular);树突细胞(Dendritic Cells);表位(Epitopes);大肠杆菌(Escherichia coli);乙型肝炎抗体(Hepatitis B Antibodies);乙型肝炎核心抗原(Hepatitis B Core Antigens);乙型肝炎疫苗(Hepatitis B Vaccines);乙型肝炎病毒(Hepatitis B virus);人类(Humans);免疫疗法(Immunotherapy);干扰素γ(Interferon-gamma);肝肿瘤(Liver Neoplasms);男(雄)性(Male);黑素瘤特异性抗原(Melanoma-Specific Antigens);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);肿瘤蛋白质类(Neoplasm Proteins);重组融合蛋白质类(Recombinant Fusion Proteins);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic);治疗结果(Treatment Outcome);肿瘤细胞, 培养的(Tumor Cells, Cultured);疫苗, 合成(Vaccines, Synthetic)
DOI
10.1016/j.cellimm.2007.07.003
PMID
17707782
发布时间
2018-12-01
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Cellular immunology
18-27页
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