换一批
换一批Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.
第一作者：
Yuxin,Qin
第一单位：
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
作者：
主题词
腺苷三磷酸酶类(Adenosine Triphosphatases);腺苷三磷酸(Adenosine Triphosphate);抗原, 肿瘤(Antigens, Neoplasm);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);细胞增殖(Cell Proliferation);DNA损伤(DNA Damage);DNA拓扑异构酶类, Ⅱ型(DNA Topoisomerases, Type II);DNA结合蛋白质类(DNA-Binding Proteins);抗药性, 肿瘤(Drug Resistance, Neoplasm);依托泊甙(Etoposide);流式细胞术(Flow Cytometry);基因, MDR(Genes, MDR);人类(Humans);水解作用(Hydrolysis);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);肿瘤(Neoplasms);磷酰化(Phosphorylation);RNA干扰(RNA Interference);表面等离激元(Surface Plasmon Resonance);拓扑异构酶II抑制剂(Topoisomerase II Inhibitors);肿瘤干细胞测定(Tumor Stem Cell Assay);山吨类(Xanthones)
DOI
10.1158/1535-7163.MCT-07-0147
PMID
17876042
发布时间
2020-09-30
- 浏览7
Molecular cancer therapeutics
2429-40页
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