换一批Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
第一作者：
Anne,Zuse
第一单位：
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, CancerCare Manitoba, ON6010-675 McDermot Avenue, Winnipeg, Canada.
作者：
主题词
蒽类(Anthracenes);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);秋水仙碱(Colchicine);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);萘类(Naphthalenes);诺考达唑(Nocodazole);鬼臼毒素(Podophyllotoxin);构效关系(Structure-Activity Relationship);噻吩类(Thiophenes);微管蛋白(Tubulin);微管蛋白调节因子(Tubulin Modulators)
DOI
10.1021/jm0708984
PMID
17973361
发布时间
2013-11-21
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