Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
第一作者:
P,Martin
第一单位:
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
作者:
医学主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);芳基烃羟化酶类(Aryl Hydrocarbon Hydroxylases);Caco-2细胞(Caco-2 Cells);细胞培养技术(Cell Culture Techniques);细胞, 培养的(Cells, Cultured);鹅脱氧胆酸(Chenodeoxycholic Acid);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA结合蛋白质类(DNA-Binding Proteins);地塞米松(Dexamethasone);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶诱导(Enzyme Induction);上皮细胞(Epithelial Cells);肝细胞(Hepatocytes);人类(Humans);肠黏膜(Intestinal Mucosa);膜转运蛋白质类(Membrane Transport Proteins);多药耐药相关蛋白质类(Multidrug Resistance-Associated Proteins);氧化还原酶类, N-脱甲基(Oxidoreductases, N-Demethylating);苯巴比妥(Phenobarbital);孕烯诺龙酮腈(Pregnenolone Carbonitrile);RNA, 信使(RNA, Messenger);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);受体, 类固醇(Receptors, Steroid);研究设计(Research Design);利福平(Rifampin);转录因子(Transcription Factors);增量调节(Up-Regulation)
DOI
10.1038/sj.bjp.0707601
PMID
18037906
发布时间
2021-12-03
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