换一批IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses.
第一作者：
Yvonne M,Mueller
第一单位：
Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
作者：
医学主题词
动物(Animals);抗体, 病毒(Antibodies, Viral);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);基因产物, gag(Gene Products, gag);白细胞介素15(Interleukin-15);Ki-67抗原(Ki-67 Antigen);杀伤细胞, 天然(Killer Cells, Natural);淋巴结(Lymph Nodes);淋巴细胞活化(Lymphocyte Activation);猕猴(Macaca mulatta);脑膜脑炎(Meningoencephalitis);受体, CCR5(Receptors, CCR5);猴获得性免疫缺陷综合征(Simian Acquired Immunodeficiency Syndrome);病毒载量(Viral Load);病毒血症(Viremia);病毒复制(Virus Replication)
DOI
10.4049/jimmunol.180.1.350
PMID
18097036
发布时间
2025-05-29
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