The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
作者:
主题词
年龄因素(Age Factors);动物(Animals);细胞死亡(Cell Death);洗涤剂(Detergents);疾病模型, 动物(Disease Models, Animal);基因表达(Gene Expression);人类(Humans);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);显微镜检查, 电子, 透射(Microscopy, Electron, Transmission);突变(Mutation);神经原纤维缠结(Neurofibrillary Tangles);神经元(Neurons);磷酰化(Phosphorylation);蛋白质结构, 三级(Protein Structure, Tertiary);肌氨酸(Sarcosine);银染色法(Silver Staining);突触(Synapses);Tau病变(Tauopathies);tau蛋白质类(tau Proteins)
DOI
10.1523/JNEUROSCI.2824-07.2008
PMID
18199773
发布时间
2020-02-25
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