换一批Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.
第一作者：
Eun Kyoung,Ryu
第一单位：
Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
作者：
医学主题词
动物(Animals);结合, 竞争性(Binding, Competitive);脑(Brain);二肽类(Dipeptides);药物设计(Drug Design);氟放射性同位素(Fluorine Radioisotopes);豚鼠(Guinea Pigs);同位素标记(Isotope Labeling);男(雄)性(Male);小鼠(Mice);分子构象(Molecular Conformation);正电子发射断层显像术(Positron-Emission Tomography);放射配体测定(Radioligand Assay);放射性药物(Radiopharmaceuticals);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 阿片样, δ(Receptors, Opioid, delta);受体, 阿片样, μ(Receptors, Opioid, mu);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);四氢异喹啉类(Tetrahydroisoquinolines)
DOI
10.1021/jm7014765
PMID
18311909
发布时间
2025-05-29
基金项目
Z01 ES100472/ImNIH/Intramural NIH HHS/United States
R21 CA102123/CA/NCI NIH HHS/United States
R01 CA 119053/CA/NCI NIH HHS/United States
Z01 ES090053/ImNIH/Intramural NIH HHS/United States
R01 CA119053/CA/NCI NIH HHS/United States
Z99 ES999999/ImNIH/Intramural NIH HHS/United States
P50 CA 114747/CA/NCI NIH HHS/United States
R21 CA121842/CA/NCI NIH HHS/United States
R21 CA 102123/CA/NCI NIH HHS/United States
R21 CA 121842/CA/NCI NIH HHS/United States
P50 CA114747/CA/NCI NIH HHS/United States
- 浏览11
Journal of medicinal chemistry
1817-23页
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