The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.
第一作者:
Bin,Zhang
第一单位:
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129-2060, USA.
作者:
主题词
淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β肽类(Amyloid beta-Peptides);麻醉药, 吸入(Anesthetics, Inhalation);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);氨甲酸酯类(Carbamates);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞低氧(Cell Hypoxia);细胞系, 肿瘤(Cell Line, Tumor);氯碘羟喹(Clioquinol);二肽类(Dipeptides);酶激活(Enzyme Activation);人类(Humans);异氟醚(Isoflurane);模型, 生物学(Models, Biological);寡肽类(Oligopeptides);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质结构, 四级(Protein Structure, Quaternary)
DOI
10.1074/jbc.M800199200
PMID
18326038
发布时间
2024-11-17
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