Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.
作者:
主题词
主动转运, 细胞核(Active Transport, Cell Nucleus);动物(Animals);氧化偶氮甲烷(Azoxymethane);Caco-2细胞(Caco-2 Cells);细胞增殖(Cell Proliferation);细胞转化, 肿瘤(Cell Transformation, Neoplastic);结肠(Colon);结肠肿瘤(Colonic Neoplasms);上皮细胞(Epithelial Cells);女(雌)性(Female);HT29细胞(HT29 Cells);人类(Humans);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 基因敲除(Mice, Knockout);PPARγ(PPAR gamma);蛋白质结合(Protein Binding);RNA干扰(RNA Interference);信号传导(Signal Transduction);TCF转录因子类(TCF Transcription Factors);噻唑烷二酮类(Thiazolidinediones);时间因素(Time Factors);转染(Transfection);β连环素(beta Catenin)
DOI
10.1254/jphs.fp0071766
PMID
18391483
发布时间
2019-09-11
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