Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry.
作者:
主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);关节炎, 类风湿(Arthritis, Rheumatoid);狨猴属(Callithrix);碳同位素(Carbon Isotopes);色谱法, 液相(Chromatography, Liquid);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);氮同位素(Nitrogen Isotopes);肽类(Peptides);敏感性与特异性(Sensitivity and Specificity);染色与标记(Staining and Labeling);串联质谱法(Tandem Mass Spectrometry)
DOI
10.1021/ac800205s
PMID
18465883
发布时间
2008-06-02
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Analytical chemistry
4200-7页
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