换一批
换一批Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
第一作者：
John C,McKew
第一单位：
Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA. jmckew@wyeth.com
作者：
主题词
动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);关节炎, 实验性(Arthritis, Experimental);苯甲酸盐类(Benzoates);生物利用度(Biological Availability);支气管收缩(Bronchoconstriction);量热法(Calorimetry);角叉菜胶(Carrageenan);细胞系(Cell Line);环氧化酶2抑制剂(Cyclooxygenase 2 Inhibitors);水肿(Edema);Ⅳ型磷脂酶A2(Group IV Phospholipases A2);人类(Humans);同工酶类(Isoenzymes);男(雄)性(Male);小鼠(Mice);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);绵羊(Sheep);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides)
DOI
10.1021/jm701467e
PMID
18498150
发布时间
2019-01-09
- 浏览23
Journal of medicinal chemistry
3388-413页
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