换一批
换一批A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies.
作者：
主题词
乙酸盐类(Acetates);投药, 口服(Administration, Oral);投药, 舌下(Administration, Sublingual);动物(Animals);生物利用度(Biological Availability);缓冲剂(Buffers);色谱法, 液相(Chromatography, Liquid);环核苷酸磷酸二酯酶类, 5型(Cyclic Nucleotide Phosphodiesterases, Type 5);药物评价, 临床前(Drug Evaluation, Preclinical);药物稳定性(Drug Stability);禁食(Fasting);氢离子浓度(Hydrogen-Ion Concentration);注射, 静脉内(Injections, Intravenous);男(雄)性(Male);甲醇(Methanol);分子结构(Molecular Structure);磷酸二酯酶5抑制剂(Phosphodiesterase 5 Inhibitors);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);嘧啶酮类(Pyrimidinones);吡咯类(Pyrroles);质量控制(Quality Control);随机分配(Random Allocation);大鼠(Rats);大鼠, Wistar(Rats, Wistar);参考标准(Reference Standards);结果可重复性(Reproducibility of Results);敏感性与特异性(Sensitivity and Specificity);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);串联质谱法(Tandem Mass Spectrometry);时间因素(Time Factors)
DOI
10.1016/j.jpba.2008.04.004
PMID
18499386
发布时间
2019-12-10
- 浏览6
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
