换一批Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5.
第一作者：
Yinling,Lin
第一单位：
Novartis Vaccine and Diagnostic, Inc., Emeryville, California 94608, USA. yinlilin918@yahoo.com
作者：
医学主题词
佐剂, 免疫(Adjuvants, Immunologic);甲病毒属(Alphavirus);动物(Animals);抗体, 病毒(Antibodies, Viral);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);胆固醇(Cholesterol);交叉反应(Cross Reactions);细胞因子类(Cytokines);复方合剂(Drug Combinations);女(雌)性(Female);遗传载体(Genetic Vectors);肝炎病毒属(Hepacivirus);免疫接种, 加强(Immunization, Secondary);白细胞, 单核(Leukocytes, Mononuclear);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);中和试验(Neutralization Tests);磷脂类(Phospholipids);聚山梨醇酯类(Polysorbates);皂苷类(Saponins);脾(Spleen);角鲨烯(Squalene);疫苗, 合成(Vaccines, Synthetic);病毒性肝炎疫苗(Viral Hepatitis Vaccines);病毒蛋白质类(Viral Proteins)
DOI
10.1128/JVI.02743-07
PMID
18508900
发布时间
2021-10-20
- 浏览105
Journal of virology
7492-503页
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