Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway.
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);腺病毒科(Adenoviridae);动物(Animals);细胞分化(Cell Differentiation);细胞系(Cell Line);人类(Humans);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);MAP激酶信号系统(MAP Kinase Signaling System);小鼠(Mice);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);肌肉发育(Muscle Development);成肌细胞(Myoblasts);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);磷酰化(Phosphorylation);蛋白质酪氨酸磷酸酶, 非受体11型(Protein Tyrosine Phosphatase, Non-Receptor Type 11);RNA, 小分子干扰(RNA, Small Interfering);转导, 遗传(Transduction, Genetic)
DOI
10.1074/jbc.M803907200
PMID
18577518
发布时间
2021-10-20
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