换一批Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
第一作者：
S,Sarkar
第一单位：
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
作者：
医学主题词
动物(Animals);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);自噬(Autophagy);疾病模型, 动物(Disease Models, Animal);果蝇属(Drosophila);基因表达调控(Gene Expression Regulation);人类(Humans);突变(Mutation);神经组织蛋白质类(Nerve Tissue Proteins);神经变性疾病(Neurodegenerative Diseases);核蛋白质类(Nuclear Proteins);肽类(Peptides);蛋白质生物合成(Protein Biosynthesis);蛋白激酶类(Protein Kinases);信号传导(Signal Transduction);西罗莫司(Sirolimus);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)
DOI
10.1038/cdd.2008.110
PMID
18636076
发布时间
2025-05-29
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