换一批
换一批Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
第一作者：
Qingzhong,Hu
第一单位：
Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 151150, D-66041 Saarbrücken, Germany.
作者：
主题词
动物(Animals);结合部位(Binding Sites);联苯化合物(Biphenyl Compounds);酶抑制剂(Enzyme Inhibitors);人类(Humans);咪唑类(Imidazoles);半数抑制浓度(Inhibitory Concentration 50);磁共振波谱学(Magnetic Resonance Spectroscopy);男(雄)性(Male);模型, 分子(Models, Molecular);蛋白质结构, 二级(Protein Structure, Secondary);大鼠(Rats);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);分光光度法, 红外线(Spectrophotometry, Infrared);类固醇17-α-羟化酶(Steroid 17-alpha-Hydroxylase);睾酮(Testosterone)
DOI
10.1016/j.bmc.2008.07.011
PMID
18674917
发布时间
2016-11-24
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