换一批Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
第一作者：
Steven,Fletcher
第一单位：
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, USA.
作者：
医学主题词
动物(Animals);抗疟药(Antimalarials);药物设计(Drug Design);酶抑制剂(Enzyme Inhibitors);乙二胺类(Ethylenediamines);法尼基转转移酶(Farnesyltranstransferase);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);疟原虫属(Plasmodium);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm800113p
PMID
18686940
发布时间
2025-05-29
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