The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.
第一作者:
Matthew K,Summers
第一单位:
Department of Cellular Regulation, Genentech Inc., South San Francisco, CA 94080, USA.
作者:
主题词
氨基酸序列(Amino Acid Sequence);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);人类(Humans);赖氨酸(Lysine);磁共振波谱学(Magnetic Resonance Spectroscopy);分子序列数据(Molecular Sequence Data);蛋白质结构, 三级(Protein Structure, Tertiary);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity);泛素缀合酶类(Ubiquitin-Conjugating Enzymes);泛素蛋白连接酶复合物(Ubiquitin-Protein Ligase Complexes);泛素化(Ubiquitination)
DOI
10.1016/j.molcel.2008.07.014
PMID
18722180
发布时间
2022-03-31
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Molecular cell
544-556页
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