Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation.
作者:
主题词
生物碱类(Alkaloids);动物(Animals);主动脉(Aorta);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);DNA(DNA);剂量效应关系, 药物(Dose-Response Relationship, Drug);中草药(Drugs, Chinese Herbal);吲哚生物碱类(Indole Alkaloids);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);肌, 平滑, 血管(Muscle, Smooth, Vascular);磷酰化(Phosphorylation);植物组成部分, 地上(Plant Components, Aerial);血小板源性生长因子(Platelet-Derived Growth Factor);原癌基因蛋白质c-sis(Proto-Oncogene Proteins c-sis);大鼠(Rats);钩藤属(Uncaria)
DOI
10.1248/bpb.31.2073
PMID
18981576
发布时间
2019-07-20
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