The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.
第一作者:
Ralf,Schröder
第一单位:
Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
作者:
主题词
氨基酸序列(Amino Acid Sequence);抑制蛋白类(Arrestins);细胞系(Cell Line);环AMP(Cyclic AMP);细胞外信号调节MAP激酶类(Extracellular Signal-Regulated MAP Kinases);GTP结合蛋白质α亚单位, Gi-Go(GTP-Binding Protein alpha Subunits, Gi-Go);鸟苷5'-O-(3-硫代三磷酸)(Guanosine 5'-O-(3-Thiotriphosphate));人类(Humans);分子序列数据(Molecular Sequence Data);磷酰化(Phosphorylation);前列腺素D2(Prostaglandin D2);蛋白质结合(Protein Binding);受体, 免疫(Receptors, Immunologic);受体, 前列腺素(Receptors, Prostaglandin);序列比对(Sequence Alignment);信号传导(Signal Transduction);底物特异性(Substrate Specificity);时间因素(Time Factors);转录激活(Transcriptional Activation)
DOI
10.1074/jbc.M806867200
PMID
19010788
发布时间
2021-02-06
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