换一批
换一批Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
作者：
主题词
阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);结晶学, X线(Crystallography, X-Ray);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);酶抑制剂(Enzyme Inhibitors);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);模型, 分子(Models, Molecular);分子构象(Molecular Conformation);受体, Notch1(Receptor, Notch1);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides);噻吩类(Thiophenes)
DOI
10.1021/jm801252w
PMID
19012391
发布时间
2012-11-15
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