换一批
换一批Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).
作者：
主题词
乙酰胺类(Acetamides);黏着素, 大肠杆菌(Adhesins, Escherichia coli);动物(Animals);抗病毒药(Antiviral Agents);生物转运(Biological Transport);血脑屏障(Blood-Brain Barrier);脑(Brain);细胞, 培养的(Cells, Cultured);女(雌)性(Female);基因敲除技术(Gene Knockout Techniques);人类(Humans);男(雄)性(Male);小鼠(Mice);多药耐药相关蛋白质类(Multidrug Resistance-Associated Proteins);有机阴离子转运子, 非钠依赖(Organic Anion Transporters, Sodium-Independent);奥司他韦(Oseltamivir);生理学现象(Physiological Phenomena);组织分布(Tissue Distribution)
DOI
10.1124/dmd.108.024018
PMID
19029202
发布时间
2025-02-12
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