INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice.
第一作者:
Xiang-Ying,Jiao
第一单位:
Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
作者:
主题词
动物(Animals);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶激活(Enzyme Activation);心脏(Heart);男(雄)性(Male);金属卟啉类(Metalloporphyrins);小鼠(Mice);心肌梗死(Myocardial Infarction);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);氧化性应激(Oxidative Stress);过氧亚硝酸(Peroxynitrous Acid);再灌注损伤(Reperfusion Injury)
DOI
10.1124/jpet.108.144352
PMID
19033557
发布时间
2025-03-06
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