换一批Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.
第一作者：
Anne,Moenning
第一单位：
Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany.
作者：
医学主题词
动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);颅缝早闭(Craniosynostoses);酶激活(Enzyme Activation);基因表达调控(Gene Expression Regulation);人类(Humans);整合酶类(Integrases);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);突变(Mutation);神经嵴(Neural Crest);成骨细胞(Osteoblasts);磷脂酶Cγ(Phospholipase C gamma);磷酰化(Phosphorylation);受体, 血小板源生长因子α(Receptor, Platelet-Derived Growth Factor alpha);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);序列分析, DNA(Sequence Analysis, DNA);信号传导(Signal Transduction);颅骨(Skull);干细胞(Stem Cells);转基因(Transgenes)
DOI
10.1128/MCB.00885-08
PMID
19047372
发布时间
2021-10-20
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