Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors.
作者:
主题词
消炎药(Anti-Inflammatory Agents);细胞凋亡(Apoptosis);结合, 竞争性(Binding, Competitive);硼酸化物(Boronic Acids);细胞, 培养的(Cells, Cultured);染色体缺失(Chromosome Deletion);染色体, 人, 13对(Chromosomes, Human, Pair 13);地塞米松(Dexamethasone);二肽类(Dipeptides);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物协同作用(Drug Synergism);内皮, 血管(Endothelium, Vascular);人类(Humans);免疫印迹法(Immunoblotting);多发性骨髓瘤(Multiple Myeloma);胰腺肿瘤(Pancreatic Neoplasms);蛋白酶抑制药(Protease Inhibitors);吡嗪类(Pyrazines);RNA, 信使(RNA, Messenger);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);脐静脉(Umbilical Veins)
DOI
10.1182/blood-2008-07-171637
PMID
19050304
发布时间
2021-10-20
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Blood
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