Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
第一作者:
Christophe A,Girard
第一单位:
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
作者:
医学主题词
腺苷三磷酸(Adenosine Triphosphate);动物(Animals);钙(Calcium);糖尿病(Diabetes Mellitus);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);降血糖药(Hypoglycemic Agents);婴儿, 新生(Infant, Newborn);胰岛素分泌细胞(Insulin-Secreting Cells);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);突变(Mutation);膜片钳术(Patch-Clamp Techniques);钾通道, 内向整流(Potassium Channels, Inwardly Rectifying);蛋白质亚单位(Protein Subunits);甲苯磺丁脲(Tolbutamide)
DOI
10.1172/JCI35772
PMID
19065048
发布时间
2025-05-29
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