换一批Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity.
第一作者：
Nathan T,Ihle
第一单位：
The University of Texas M. D. Anderson Cancer Center, FC-6.3044, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
作者：
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);疾病恶化(Disease Progression);葡萄糖(Glucose);葡萄糖转运蛋白质类, 易化性(Glucose Transport Proteins, Facilitative);葡糖-6-磷酸盐(Glucose-6-Phosphate);甾烷(Gonanes);人类(Humans);高血糖症(Hyperglycemia);小鼠(Mice);肿瘤(Neoplasms);PPARγ(PPAR gamma);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);信号传导(Signal Transduction);噻唑烷二酮类(Thiazolidinediones);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1535-7163.MCT-08-0714
PMID
19139117
发布时间
2025-05-29
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