Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation.
作者:
主题词
碱基序列(Base Sequence);染色体, 人, 22对(Chromosomes, Human, Pair 22);染色体, 人, 6对(Chromosomes, Human, Pair 6);DNA(DNA);DNA引物(DNA Primers);电泳迁移位移试验(Electrophoretic Mobility Shift Assay);基因, 显性(Genes, Dominant);人类(Humans);诱变, 定点(Mutagenesis, Site-Directed);八聚体转录因子3(Octamer Transcription Factor-3);癌基因(Oncogenes);RNA结合蛋白质EWS(RNA-Binding Protein EWS);转录激活(Transcriptional Activation)
DOI
10.1002/ijc.24228
PMID
19170206
发布时间
2016-03-03
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