换一批New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
第一作者：
Diane E,McCloskey
第一单位：
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
作者：
医学主题词
腺嘌呤(Adenine);腺苷甲硫氨酸脱羧酶(Adenosylmethionine Decarboxylase);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);人类(Humans);模型, 分子(Models, Molecular);突变(Mutation);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);S-腺苷甲硫氨酸(S-Adenosylmethionine);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm801126a
PMID
19209891
发布时间
2025-01-04
- 浏览23
Journal of medicinal chemistry
1388-407页
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