Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor.
第一作者:
Kenneth L,Seldeen
第一单位:
Department of Biochemistry and Molecular Biology and the UM/SylVester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, UniVersity of Miami, Miami, Florida 33136, USA.
作者:
医学主题词
氨基酸序列(Amino Acid Sequence);碱基序列(Base Sequence);碱性亮氨酸拉链转录因子类(Basic-Leucine Zipper Transcription Factors);结合部位(Binding Sites);结合, 竞争性(Binding, Competitive);量热法(Calorimetry);DNA(DNA);熵(Entropy);人类(Humans);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);寡核苷酸类(Oligonucleotides);点突变(Point Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide);蛋白质结合(Protein Binding);蛋白质多聚化(Protein Multimerization);蛋白质结构, 四级(Protein Structure, Quaternary);蛋白质结构, 三级(Protein Structure, Tertiary);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);原癌基因蛋白质c-jun(Proto-Oncogene Proteins c-jun);序列同源性, 氨基酸(Sequence Homology, Amino Acid);热力学(Thermodynamics);滴定分析法(Titrimetry)
DOI
10.1021/bi802068s
PMID
19215067
发布时间
2025-05-29
- 浏览15
Biochemistry
1975-83页
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