N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

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作者： Palmarisa,Franchetti ^[1] ; Loredana,Cappellacci ; Patrizia,Vita ; Riccardo,Petrelli ; Antonio,Lavecchia ; Sonja,Kachler ; Karl-Norbert,Klotz ; Ida,Marabese ; Livio,Luongo ; Sabatino,Maione ; Mario,Grifantini

作者单位： Department of Chemical Sciences, University of Camerino, 62032 Camerino, Italy. ^[1]

主题词腺苷(Adenosine);腺苷A1受体激动剂(Adenosine A1 Receptor Agonists);镇痛药(Analgesics);动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);环戊烷类(Cyclopentanes);人类(Humans);小鼠(Mice);模型, 分子(Models, Molecular);原冰片烷类(Norbornanes);疼痛测定(Pain Measurement);放射配体测定(Radioligand Assay);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)

DOI 10.1021/jm801456g

PMID 19317449

发布时间 2015-11-19

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Journal of medicinal chemistry

2009年52卷8期

2393-406页

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N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

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