The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.
作者:
主题词
3T3-L1细胞(3T3-L1 Cells);脂细胞(Adipocytes);成脂分化(Adipogenesis);动物(Animals);CCAAT增强子结合蛋白β(CCAAT-Enhancer-Binding Protein-beta);载体蛋白质类(Carrier Proteins);细胞分化(Cell Differentiation);染色质(Chromatin);DNA(DNA);E1A相关p300蛋白质(E1A-Associated p300 Protein);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);小鼠(Mice);核受体亚家族1, F组, 成员1(Nuclear Receptor Subfamily 1, Group F, Member 1);PPARγ(PPAR gamma);磷蛋白类(Phosphoproteins);磷酰化(Phosphorylation);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);反式激活因子类(Trans-Activators);转录, 遗传(Transcription, Genetic)
DOI
10.1210/me.2008-0277
PMID
19324970
发布时间
2021-10-20
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