换一批AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells.
第一作者：
Pedro J,Beltran
第一单位：
Oncology Research Therapeutic Area, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA. pbeltran@amgen.com
作者：
医学主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);脱氧胞苷(Deoxycytidine);药物协同作用(Drug Synergism);女(雌)性(Female);人类(Humans);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);胰岛素样生长因子Ⅱ(Insulin-Like Growth Factor II);小鼠(Mice);小鼠, 裸(Mice, Nude);胰腺肿瘤(Pancreatic Neoplasms);蛋白质结合(Protein Binding);受体, IGF1型(Receptor, IGF Type 1);受体, 胰岛素(Receptor, Insulin);信号传导(Signal Transduction);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1535-7163.MCT-08-1171
PMID
19366899
发布时间
2022-12-07
- 浏览28
Molecular cancer therapeutics
1095-105页
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