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首页> The Journal of biological chemistry> Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

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作者： David,Grandy ^[1] ; Jufang,Shan ^[2] ; Xinxin,Zhang ^[1] ; Sujata,Rao ^[3] ; Shailaja,Akunuru ^[3] ; Hongyan,Li ^[4] ; Yanhui,Zhang ^[5] ; Ivan,Alpatov ^[5] ; Xin A,Zhang ^[5] ; Richard A,Lang ^[3] ; De-Li,Shi ^[4] ; Jie J,Zheng ^[6]

作者单位： From the Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105. ^[1] From the Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; Interdisciplinary Graduate Program, Memphis, Tennessee 38163. ^[2] Department of Ophthalmology and Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229. ^[3] Laboratoire de Biologie du Dévelopement, CNRS UMR 7622, University Pierre et Marie Curie, 9 Quai Saint-Bernard, 75005 Paris, France. ^[4] Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163. ^[5] From the Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; Department of Molecular Sciences, Memphis, Tennessee 38163. Electronic address: jie.zheng@stjude.org. ^[6]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);细胞凋亡(Apoptosis);苯甲酸盐类(Benzoates);细胞分裂(Cell Division);细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);晶体学(Crystallography);女(雌)性(Female);男(雄)性(Male);核磁共振, 生物分子(Nuclear Magnetic Resonance, Biomolecular);卵母细胞(Oocytes);PDZ结构域(PDZ Domains);磷蛋白类(Phosphoproteins);前列腺肿瘤(Prostatic Neoplasms);信号传导(Signal Transduction);Wnt蛋白质类(Wnt Proteins);爪蟾蛋白质类(Xenopus Proteins);光滑爪蟾(Xenopus laevis)

DOI 10.1074/jbc.M109.009647

PMID 19383605

发布时间 2021-10-20

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The Journal of biological chemistry

The Journal of biological chemistry

2009年284卷24期

16256-16263页

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