Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.

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作者： Kensuke,Kobayashi ^[1] ; Tetsuya,Kato ; Izumi,Yamamoto ; Atsushi,Shimizu ; Sayaka,Mizutani ; Masanori,Asai ; Hiroshi,Kawamoto ; Satoru,Ito ; Takashi,Yoshizumi ; Mioko,Hirayama ; Satoshi,Ozaki ; Hisashi,Ohta ; Osamu,Okamoto

作者单位： Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan. ^[1]

主题词苯咪唑类(Benzimidazoles);环己烷类(Cyclohexanes);快速延迟整流钾通道(Ether-A-Go-Go Potassium Channels);麻醉品拮抗药(Narcotic Antagonists);受体, 阿片样(Receptors, Opioid);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2009.04.022

PMID 19398200

发布时间 2022-12-07

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Bioorganic & medicinal chemistry letters

2009年19卷11期

3100-3页

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Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

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Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.

Bioorganic & medicinal chemistry letters

相似文献

Bioorganic & medicinal chemistry letters

相关期刊

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