GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
第一作者:
Grushenka H I,Wolfgang
第一单位:
Gilead Sciences, 333 Lakeside Drive, Foster City, CA, USA. gwolfgang@gilead.com
作者:
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);抗病毒药(Antiviral Agents);细胞周期(Cell Cycle);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);女(雌)性(Female);鸟嘌呤(Guanine);人类(Humans);男(雄)性(Male);核酸合成抑制剂(Nucleic Acid Synthesis Inhibitors);苯丙氨酸(Phenylalanine);药物前体(Prodrugs);兔(Rabbits);宫颈肿瘤(Uterine Cervical Neoplasms)
DOI
10.1128/AAC.00103-09
PMID
19398642
发布时间
2025-05-29
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