The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines.
第一作者:
Michael B,Prystowsky
第一单位:
Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA. prystows@aecom.yu.edu
作者:
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);癌, 鳞状细胞(Carcinoma, Squamous Cell);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);减量调节(Down-Regulation);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);流式细胞术(Flow Cytometry);G2期(G2 Phase);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);头颈部肿瘤(Head and Neck Neoplasms);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);羟肟酸类(Hydroxamic Acids);吲哚类(Indoles);男(雄)性(Male);中年人(Middle Aged);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis)
DOI
10.1002/path.2554
PMID
19402126
发布时间
2018-12-01
- 浏览2
The Journal of pathology
467-77页
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