换一批Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway.
第一作者：
Ines,Barone
第一单位：
Breast Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
作者：
医学主题词
氨基酸取代(Amino Acid Substitution);动物(Animals);精氨酸(Arginine);芳香酶抑制剂(Aromatase Inhibitors);乳腺肿瘤(Breast Neoplasms);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);抗药性, 肿瘤(Drug Resistance, Neoplasm);雌激素受体α(Estrogen Receptor alpha);女(雌)性(Female);人类(Humans);赖氨酸(Lysine);小鼠(Mice);小鼠, 裸(Mice, Nude);突变, 误义(Mutation, Missense);癌基因蛋白质v-akt(Oncogene Protein v-akt);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);预后(Prognosis);信号传导(Signal Transduction);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/0008-5472.CAN-08-4194
PMID
19487288
发布时间
2025-05-29
- 浏览41
Cancer research
4724-32页
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