换一批
换一批Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
第一作者：
Dafydd R,Owen
第一单位：
Department of Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
作者：
主题词
3',5'-环GMP磷酸二酯酶类(3',5'-Cyclic-GMP Phosphodiesterases);动物(Animals);催化域(Catalytic Domain);化学, 药物(Chemistry, Pharmaceutical);结晶学, X线(Crystallography, X-Ray);环核苷酸磷酸二酯酶类, 5型(Cyclic Nucleotide Phosphodiesterases, Type 5);环核苷酸磷酸二酯酶类, 6型(Cyclic Nucleotide Phosphodiesterases, Type 6);药物设计(Drug Design);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);半数抑制浓度(Inhibitory Concentration 50);磷酸二酯酶5抑制剂(Phosphodiesterase 5 Inhibitors);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);蛋白质结构, 三级(Protein Structure, Tertiary);吡嗪类(Pyrazines);大鼠(Rats);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bmcl.2009.06.012
PMID
19540112
发布时间
2020-12-09
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