Transcriptional down-regulation of Bcl-2 by vinorelbine: identification of a novel binding site of p53 on Bcl-2 promoter.
作者:
主题词
抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);碱基序列(Base Sequence);结合部位(Binding Sites);印迹法, 蛋白质(Blotting, Western);细胞系, 肿瘤(Cell Line, Tumor);染色质免疫沉淀法(Chromatin Immunoprecipitation);DNA引物(DNA Primers);减量调节(Down-Regulation);人类(Humans);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);转录, 遗传(Transcription, Genetic);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);长春碱(Vinblastine)
DOI
10.1016/j.bcp.2009.06.025
PMID
19555669
发布时间
2018-12-01
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Biochemical pharmacology
1148-56页
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