Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
作者:
主题词
动物(Animals);抗真菌药(Antifungal Agents);抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);细胞凋亡(Apoptosis);细胞, 培养的(Cells, Cultured);阿糖胞苷(Cytarabine);药物协同作用(Drug Synergism);电子自旋共振谱学(Electron Spin Resonance Spectroscopy);成纤维细胞(Fibroblasts);人类(Humans);免疫印迹法(Immunoblotting);凋亡抑制蛋白质类(Inhibitor of Apoptosis Proteins);铁(Iron);铁螯合剂(Iron Chelating Agents);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);萤光素酶类(Luciferases);肺(Lung);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);微管相关蛋白质类(Microtubule-Associated Proteins);多发性骨髓瘤(Multiple Myeloma);启动区, 遗传(Promoter Regions, Genetic);吡啶酮类(Pyridones);核苷酸还原酶类(Ribonucleotide Reductases)
DOI
10.1182/blood-2009-03-209965
PMID
19589922
发布时间
2021-10-25
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Blood
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