Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
作者:
主题词
肾上腺素能激动剂(Adrenergic Agonists);肾上腺素能β-3受体激动剂(Adrenergic beta-3 Receptor Agonists);动物(Animals);结合部位(Binding Sites);计算机模拟(Computer Simulation);结晶学, X线(Crystallography, X-Ray);狗(Dogs);药物发现(Drug Discovery);人类(Humans);模型, 化学(Models, Chemical);受体, 肾上腺素能β2(Receptors, Adrenergic, beta-2);受体, 肾上腺素能β3(Receptors, Adrenergic, beta-3);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides)
DOI
10.1016/j.bmcl.2009.06.083
PMID
19608416
发布时间
2010-11-18
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