Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
第一作者:
Daniel,Edgar
第一单位:
Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
作者:
医学主题词
衰老, 过早(Aging, Premature);动物(Animals);DNA, 线粒体(DNA, Mitochondrial);电子传递复合物Ⅰ(Electron Transport Complex I);电子传递复合物Ⅲ(Electron Transport Complex III);电子传递复合物Ⅳ(Electron Transport Complex IV);基因缺失(Gene Deletion);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 突变型(Mice, Mutant Strains);线粒体(Mitochondria);线粒体疾病(Mitochondrial Diseases);表型(Phenotype);点突变(Point Mutation)
DOI
10.1016/j.cmet.2009.06.010
PMID
19656491
发布时间
2019-12-10
- 浏览21
Cell metabolism
131-8页
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